Substrate control through per-O-methylation of cyclodextrin acids.
نویسندگان
چکیده
Per-O-methylated cyclodextrins containing a single 2-O-(2-acetate), 2-O-(3-propanoate) or a 6-carboxylate were investigated for glycosidase activity on p-nitrophenyl glycosides. The former two compounds displayed enzyme catalysis giving rate accelerations of 500-1000, while the latter compound gave marginal catalysis. These results show that per-O-methylated cyclodextrins direct substrate binding from the secondary face leading to better catalysis.
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ورودعنوان ژورنال:
- Chemical communications
دوره 46 41 شماره
صفحات -
تاریخ انتشار 2010